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Original Article

July 1, 2025


Distinct microbial signatures of liquid biopsy samples during gastric carcinogenesis and insights from extracellular vesicle analysis
Hee Sang You, Jae Yong Park, Hochan Seo, et al.
Korean J Intern Med. 2025;40(4):571-583.

1. Microbial diversity, particularly alpha and beta diversities, varies across different stages of gastric carcinogenesis, with notable changes in gastric juice and serum. 2. Distinct microbial signatures, including specific bacterial species...

Original Article

June 30, 2025


Prevalence of cholesterol gallstones in a Korean population over a 14-year period
Gyumin Lee, Jeong Yoon Suh, Junyeol Kim, et al.
Korean J Intern Med. 2025;40(4):584-591.

1. The proportion of cholesterol gallstones was 53.8% in the study population over 14-years period and 77.5% among individuals under the age of 50. 2. Central obesity and elevated fasting blood...

Original Article

July 1, 2025


Submucosal saline injection and mini-probe endoscopic ultrasound to assess endoscopic resectability of colorectal subepithelial tumors
Jung-Bin Park, Ji Eun Baek, June Hwa Bae, et al.
Korean J Intern Med. 2025;40(4):592-605.

1. Therapeutic decision-making for colorectal SELs can be challenging, and the endoscopic non-lifting sign after SSI is not objectively measurable. However, submucosal cushion thickness (the distance between the SEL base...

Original Article

July 1, 2025


Impact of body mass index on clinical outcomes in intestinal Behçet’s disease
Daye Park, Jihye Park, Soo Jung Park, et al.
Korean J Intern Med. 2025;40(4):606-615.

1. Underweight patients with intestinal BD experienced significantly poorer clinical outcomes, including higher rates of biologics use, surgery, hospitalization, and emergency room visits, than normal, overweight, and obese patients. 2. Routine...

Original Article

July 1, 2025


Detection rate by time period and predictors of serious arrhythmias in unexplained syncope: a multicenter implantable loop recorder registry study
Juwon Kim, Il-Young Oh, Myung-Jin Cha, et al.
Korean J Intern Med. 2025;40(4):616-625.

1. In this relatively large cohort study (n = 394), we evaluated diagnosis rate by time period after ILR implantation and identified predictors of serious arrhythmias in patients with unexplained...

Original Article

July 1, 2025


Efficacy and safety of first-line afatinib in older patients with advanced EGFR-mutated non-small cell lung cancer
Mi-Hyun Kim, Hayoung Seong, Soo Han Kim, et al.
Korean J Intern Med. 2025;40(4):626-633.

1. First-line afatinib is an effective treatment option for older patients. 2. Post-TKI management, including tissue re-biopsy and platinum-based chemotherapy, tended to be underprescribed in this age group. 3. A 30 mg...

Original Article

July 1, 2025


Clinical impacts of COVID-19 on severe exacerbation and mortality in interstitial lung disease: prognosis 30 days after infection
Bo-Guen Kim, Sun-Kyung Lee, Dong Won Park, et al.
Korean J Intern Med. 2025;40(4):634-644.

1. In this study, we evaluated the clinical impact of COVID-19 on patients with ILD. 2. We found that ILD patients who survived COVID-19 were at higher risk of severe exacerbation...

Original Article

July 1, 2025


Association between body mass index and survival after hematopoietic stem cell transplantation
Han-Sang Baek, Jong Hyuk Lee, Joonyub Lee, et al.
Korean J Intern Med. 2025;40(4):645-656.

1. A BMI below 18.5 kg/m2 is an independent risk factor for increased early mortality after HSCT. 2. Obesity was not associated with poorer outcomes, indicating BMI alone may not be...

Original Article

July 1, 2025


Decreased frequency and inflammatory change of FoxP3+ regulatory T cells in immunopathogenesis of human acute graft-versus-host disease
Nayeon Seong, Cheongin Yang, Kunye Kwak, et al.
Korean J Intern Med. 2025;40(4):657-666.

1. During human acute GvHD, frequencies of circulating Treg cells are significantly decreased. 2. Treg cells undergo inflammatory conversion, producing pro-inflammatory cytokines TNF-α and exhibiting reduced suppressive activity. 3. This conversion is...

Original Article

July 1, 2025


Cytokine profiles associated with persisting symptoms of post-acute sequelae of COVID-19
Ji-Soo Kwon, Euijin Chang, Hyeon Mu Jang, et al.
Korean J Intern Med. 2025;40(4):667-675.

1. Some PASC symptoms are associated with persistent inflammation. 2. The variation in cytokine profiles across different symptoms suggests the involvement of different pathophysiological mechanisms. 3. Symptoms exhibiting similar cytokine profiles are...

Original Article

April 1, 2025


Association of peripheral leukocyte telomere length with patients with rheumatoid arthritis with a focus on interstitial lung disease
Young Bin Joo, So-Young Bang, Su Jin Hong, et al.
Korean J Intern Med. 2025;40(4):676-686.

Background/Aims: This study investigated whether telomere length (TL) in rheumatoid arthritis (RA) patients is shorter than in controls, whether TL in RA patients with interstitial lung disease (RA-ILD) differs from...
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    • Current Issue
    Volume 40(4); Jul 2025
    Unexplained syncope: what time-to-diagnosis and risk profiles tell us
    Yoon Jung Park
    Korean J Intern Med. 2025;40(4):529-530.

    Editorial

    July 1, 2025
    Unraveling the immune responses in long COVID through cytokine profiling
    Oh-Hyun Cho
    Korean J Intern Med. 2025;40(4):531-532.

    Editorial

    July 1, 2025
    Role of catheter ablation in patients with heart failure and atrial fibrillation
    Min-Su Jung, Hyoung-Seob Park
    Korean J Intern Med. 2025;40(4):533-545.

    Review

    July 1, 2025
    Updates on lung cancer screening for early detection
    Se Hyun Kwak, Chi Young Kim, Sang Hoon Lee, et al.
    Korean J Intern Med. 2025;40(4):546-556.

    Review

    July 1, 2025
    Clinical benefits and future directions of medium cut-off membranes in hemodialysis: a comprehensive review
    Hyo Jin Kim, Sang Heon Song
    Korean J Intern Med. 2025;40(4):557-570.

    Review

    July 1, 2025
    Distinct microbial signatures of liquid biopsy samples during gastric carcinogenesis and insights from extracellular vesicle analysis
    Hee Sang You, Jae Yong Park, Hochan Seo, et al.
    Korean J Intern Med. 2025;40(4):571-583.

    Original Article

    July 1, 2025
    Prevalence of cholesterol gallstones in a Korean population over a 14-year period
    Gyumin Lee, Jeong Yoon Suh, Junyeol Kim, et al.
    Korean J Intern Med. 2025;40(4):584-591.

    Original Article

    June 30, 2025
    Submucosal saline injection and mini-probe endoscopic ultrasound to assess endoscopic resectability of colorectal subepithelial tumors
    Jung-Bin Park, Ji Eun Baek, June Hwa Bae, et al.
    Korean J Intern Med. 2025;40(4):592-605.

    Original Article

    July 1, 2025
    Impact of body mass index on clinical outcomes in intestinal Behçet’s disease
    Daye Park, Jihye Park, Soo Jung Park, et al.
    Korean J Intern Med. 2025;40(4):606-615.

    Original Article

    July 1, 2025
    Detection rate by time period and predictors of serious arrhythmias in unexplained syncope: a multicenter implantable loop recorder registry study
    Juwon Kim, Il-Young Oh, Myung-Jin Cha, et al.
    Korean J Intern Med. 2025;40(4):616-625.

    Original Article

    July 1, 2025
    Efficacy and safety of first-line afatinib in older patients with advanced EGFR-mutated non-small cell lung cancer
    Mi-Hyun Kim, Hayoung Seong, Soo Han Kim, et al.
    Korean J Intern Med. 2025;40(4):626-633.

    Original Article

    July 1, 2025
    Clinical impacts of COVID-19 on severe exacerbation and mortality in interstitial lung disease: prognosis 30 days after infection
    Bo-Guen Kim, Sun-Kyung Lee, Dong Won Park, et al.
    Korean J Intern Med. 2025;40(4):634-644.

    Original Article

    July 1, 2025
    Association between body mass index and survival after hematopoietic stem cell transplantation
    Han-Sang Baek, Jong Hyuk Lee, Joonyub Lee, et al.
    Korean J Intern Med. 2025;40(4):645-656.

    Original Article

    July 1, 2025
    Decreased frequency and inflammatory change of FoxP3+ regulatory T cells in immunopathogenesis of human acute graft-versus-host disease
    Nayeon Seong, Cheongin Yang, Kunye Kwak, et al.
    Korean J Intern Med. 2025;40(4):657-666.

    Original Article

    July 1, 2025
    Cytokine profiles associated with persisting symptoms of post-acute sequelae of COVID-19
    Ji-Soo Kwon, Euijin Chang, Hyeon Mu Jang, et al.
    Korean J Intern Med. 2025;40(4):667-675.

    Original Article

    July 1, 2025
    Association of peripheral leukocyte telomere length with patients with rheumatoid arthritis with a focus on interstitial lung disease
    Young Bin Joo, So-Young Bang, Su Jin Hong, et al.
    Korean J Intern Med. 2025;40(4):676-686.

    Original Article

    April 1, 2025
    Beat-to-beat alternans
    Chan-Hee Lee, Melvin M. Scheinman
    Korean J Intern Med. 2025;40(4):687-688.

    Image of interest

    May 21, 2025
    Generalized edema with acute renal failure in a patient with diabetes
    Yujin Shin, Chang‑Hoon Lee, Kyoung Min Kim, et al.
    Korean J Intern Med. 2025;40(4):689-690.

    Image of interest

    July 1, 2025

    Korean Journal of
    Internal Medicine

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    Online ISSN: 2005-6648

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